Cruise Ports
← Back to St. Louis port guide

Cruises Calling at St. Louis

45 upcoming cruises that stop at St. Louis, Missouri, USA. Updated regularly; always confirm with the cruise line.

ACL American Melody
American Cruise Lines Cruises
St Louis MO → Pittsburgh PA
⚓ Calls 20 Jun 202613 nights10 portsDeparts 2026 Jun 20
View itinerary · 10 ports
13 days, one-way from St Louis MO to Pittsburgh PA
  1. 20 JunDeparting from St Louis MO, Missouri
  2. 20 JunAlton IL, Illinois
  3. 21 JunPaducah KY, Kentucky
  4. 23 JunHenderson KY, Kentucky
  5. 25 JunLouisville KY, Kentucky
  6. 26 JunMadison IN, Indiana
  7. 27 JunCincinnati OH, Ohio
  8. 29 JunMaysville KY, Kentucky
  9. 01 JulMarietta OH, Ohio
  10. 03 JulArriving in Pittsburgh PA, Pennsylvania
Find this cruise to book →
$9240from / pp
ACL American Serenade
American Cruise Lines Cruises
Minneapolis-Saint Paul → St Louis MO
⚓ Calls 10 Jul 20267 nights10 portsDeparts 2026 Jul 04
View itinerary · 10 ports
7 days, one-way from Minneapolis-Saint Paul to St Louis MO
  1. 04 JulDeparting from Minneapolis-Saint Paul, Minnesota
  2. 04 JulMinneapolis-Saint Paul, Minnesota
  3. 05 JulLa Crosse WI, Wisconsin
  4. 07 JulDubuque IA, Iowa
  5. 08 JulDavenport IA, Iowa, Quad Cities
  6. 09 JulHannibal MO, Missouri
  7. 10 JulAlton IL, Illinois
  8. 10 JulSt Louis MO, Missouri
  9. 10 Jul - 11 JulAlton IL, Illinois
  10. 11 JulArriving in St Louis MO, Missouri
Find this cruise to book →
$5635from / pp
Viking Mississippi
Viking River Cruises
Minneapolis-Saint Paul → New Orleans
⚓ Calls 11 Jul 202614 nights14 portsDeparts 2026 Jul 04
View itinerary · 14 ports
14 days, one-way from Minneapolis-Saint Paul to New Orleans
  1. 04 JulDeparting from Minneapolis-Saint Paul, Minnesota
  2. 05 JulRed Wing MN, Minnesota
  3. 06 JulLa Crosse WI, Wisconsin
  4. 07 JulDubuque IA, Iowa
  5. 08 JulDavenport IA, Iowa, Quad Cities
  6. 09 JulBurlington IA, Iowa
  7. 10 JulHannibal MO, Missouri
  8. 11 JulSt Louis MO, Missouri
  9. 13 JulMemphis TN, Tennessee
  10. 14 JulGreenville MS, Mississippi
  11. 15 JulVicksburg MS, Mississippi
  12. 16 JulNatchez MS, Mississippi
  13. 17 JulBaton Rouge, Louisiana
  14. 18 JulArriving in New Orleans, Port NOLA Louisiana
Find this cruise to book →
Price on request
ACL American Serenade
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 11 Jul 20267 nights8 portsDeparts 2026 Jul 11
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 11 JulDeparting from St Louis MO, Missouri
  2. 11 JulSt Louis MO, Missouri
  3. 12 JulHannibal MO, Missouri
  4. 14 JulMuscatine IA, Iowa
  5. 15 JulDubuque IA, Iowa
  6. 16 JulWinona MN, Minnesota
  7. 17 JulRed Wing MN, Minnesota
  8. 18 JulArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5635from / pp
ACL American Serenade
American Cruise Lines Cruises
Minneapolis-Saint Paul → St Louis MO
⚓ Calls 24 Jul 20267 nights10 portsDeparts 2026 Jul 18
View itinerary · 10 ports
7 days, one-way from Minneapolis-Saint Paul to St Louis MO
  1. 18 JulDeparting from Minneapolis-Saint Paul, Minnesota
  2. 18 JulMinneapolis-Saint Paul, Minnesota
  3. 19 JulLa Crosse WI, Wisconsin
  4. 21 JulDubuque IA, Iowa
  5. 22 JulDavenport IA, Iowa, Quad Cities
  6. 23 JulHannibal MO, Missouri
  7. 24 JulAlton IL, Illinois
  8. 24 JulSt Louis MO, Missouri
  9. 24 Jul - 25 JulAlton IL, Illinois
  10. 25 JulArriving in St Louis MO, Missouri
Find this cruise to book →
$5635from / pp
ACL American Serenade
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 25 Jul 20267 nights8 portsDeparts 2026 Jul 25
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 25 JulDeparting from St Louis MO, Missouri
  2. 25 JulSt Louis MO, Missouri
  3. 26 JulHannibal MO, Missouri
  4. 28 JulMuscatine IA, Iowa
  5. 29 JulDubuque IA, Iowa
  6. 30 JulWinona MN, Minnesota
  7. 31 JulRed Wing MN, Minnesota
  8. 01 AugArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5635from / pp
Viking Mississippi
Viking River Cruises
New Orleans → Alton IL
⚓ Calls 30 Jul - 31 Jul 202614 nights11 portsDeparts 2026 Jul 18
View itinerary · 11 ports
14 days, one-way from New Orleans to Alton IL
  1. 18 JulDeparting from New Orleans, Port NOLA Louisiana
  2. 19 JulDarrow LA, Louisiana
  3. 20 JulSt Francisville LA, Louisiana
  4. 21 JulNatchez MS, Mississippi
  5. 22 JulVicksburg MS, Mississippi
  6. 23 JulGreenville MS, Mississippi
  7. 25 Jul - 26 JulMemphis TN, Tennessee
  8. 28 JulPaducah KY, Kentucky
  9. 29 JulCape Girardeau MO, Missouri
  10. 30 Jul - 31 JulSt Louis MO, Missouri
  11. 01 AugArriving in Alton IL, Illinois
Find this cruise to book →
$8999from / pp
Viking Mississippi
Viking River Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 30 Jul - 31 Jul 202621 nights18 portsDeparts 2026 Jul 18
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 18 JulDeparting from New Orleans, Port NOLA Louisiana
  2. 19 JulDarrow LA, Louisiana
  3. 20 JulSt Francisville LA, Louisiana
  4. 21 JulNatchez MS, Mississippi
  5. 22 JulVicksburg MS, Mississippi
  6. 23 JulGreenville MS, Mississippi
  7. 25 Jul - 26 JulMemphis TN, Tennessee
  8. 28 JulPaducah KY, Kentucky
  9. 29 JulCape Girardeau MO, Missouri
  10. 30 Jul - 31 JulSt Louis MO, Missouri
  11. 01 AugAlton IL, Illinois
  12. 02 AugHannibal MO, Missouri
  13. 03 AugBurlington IA, Iowa
  14. 04 AugDavenport IA, Iowa, Quad Cities
  15. 05 AugDubuque IA, Iowa
  16. 06 AugLa Crosse WI, Wisconsin
  17. 07 AugRed Wing MN, Minnesota
  18. 08 AugArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
Price on request
ACL American Serenade
American Cruise Lines Cruises
Minneapolis-Saint Paul → St Louis MO
⚓ Calls 07 Aug 20267 nights10 portsDeparts 2026 Aug 01
View itinerary · 10 ports
7 days, one-way from Minneapolis-Saint Paul to St Louis MO
  1. 01 AugDeparting from Minneapolis-Saint Paul, Minnesota
  2. 01 AugMinneapolis-Saint Paul, Minnesota
  3. 02 AugLa Crosse WI, Wisconsin
  4. 04 AugDubuque IA, Iowa
  5. 05 AugDavenport IA, Iowa, Quad Cities
  6. 06 AugHannibal MO, Missouri
  7. 07 AugAlton IL, Illinois
  8. 07 AugSt Louis MO, Missouri
  9. 07 Aug - 08 AugAlton IL, Illinois
  10. 08 AugArriving in St Louis MO, Missouri
Find this cruise to book →
$5635from / pp
ACL American Serenade
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 08 Aug 20267 nights8 portsDeparts 2026 Aug 08
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 08 AugDeparting from St Louis MO, Missouri
  2. 08 AugSt Louis MO, Missouri
  3. 09 AugHannibal MO, Missouri
  4. 11 AugMuscatine IA, Iowa
  5. 12 AugDubuque IA, Iowa
  6. 13 AugWinona MN, Minnesota
  7. 14 AugRed Wing MN, Minnesota
  8. 15 AugArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5635from / pp
ACL American Melody
American Cruise Lines Cruises
Pittsburgh PA → St Louis MO
⚓ Calls 14 Aug 202613 nights10 portsDeparts 2026 Aug 01
View itinerary · 10 ports
13 days, one-way from Pittsburgh PA to St Louis MO
  1. 01 AugDeparting from Pittsburgh PA, Pennsylvania
  2. 01 AugPittsburgh PA, Pennsylvania
  3. 03 AugMarietta OH, Ohio
  4. 05 AugMaysville KY, Kentucky
  5. 06 AugCincinnati OH, Ohio
  6. 07 AugMadison IN, Indiana
  7. 08 AugLouisville KY, Kentucky
  8. 10 AugHenderson KY, Kentucky
  9. 12 AugPaducah KY, Kentucky
  10. 14 AugArriving in St Louis MO, Missouri
Find this cruise to book →
$9240from / pp
ACL American Melody
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 15 Aug 20267 nights8 portsDeparts 2026 Aug 15
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 15 AugDeparting from St Louis MO, Missouri
  2. 15 AugSt Louis MO, Missouri
  3. 16 AugHannibal MO, Missouri
  4. 18 AugMuscatine IA, Iowa
  5. 19 AugDubuque IA, Iowa
  6. 20 AugWinona MN, Minnesota
  7. 21 AugRed Wing MN, Minnesota
  8. 22 AugArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5635from / pp
ACL American Serenade
American Cruise Lines Cruises
Minneapolis-Saint Paul → St Louis MO
⚓ Calls 21 Aug 20267 nights10 portsDeparts 2026 Aug 15
View itinerary · 10 ports
7 days, one-way from Minneapolis-Saint Paul to St Louis MO
  1. 15 AugDeparting from Minneapolis-Saint Paul, Minnesota
  2. 15 AugMinneapolis-Saint Paul, Minnesota
  3. 16 AugLa Crosse WI, Wisconsin
  4. 18 AugDubuque IA, Iowa
  5. 19 AugDavenport IA, Iowa, Quad Cities
  6. 20 AugHannibal MO, Missouri
  7. 21 AugAlton IL, Illinois
  8. 21 AugSt Louis MO, Missouri
  9. 21 Aug - 22 AugAlton IL, Illinois
  10. 22 AugArriving in St Louis MO, Missouri
Find this cruise to book →
$5635from / pp
ACL American Serenade
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 22 Aug 20267 nights8 portsDeparts 2026 Aug 22
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 22 AugDeparting from St Louis MO, Missouri
  2. 22 AugSt Louis MO, Missouri
  3. 23 AugHannibal MO, Missouri
  4. 25 AugMuscatine IA, Iowa
  5. 26 AugDubuque IA, Iowa
  6. 27 AugWinona MN, Minnesota
  7. 28 AugRed Wing MN, Minnesota
  8. 29 AugArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5635from / pp
ACL American Melody
American Cruise Lines Cruises
Minneapolis-Saint Paul → St Louis MO
⚓ Calls 28 Aug 20267 nights10 portsDeparts 2026 Aug 22
View itinerary · 10 ports
7 days, one-way from Minneapolis-Saint Paul to St Louis MO
  1. 22 AugDeparting from Minneapolis-Saint Paul, Minnesota
  2. 22 AugMinneapolis-Saint Paul, Minnesota
  3. 23 AugLa Crosse WI, Wisconsin
  4. 25 AugDubuque IA, Iowa
  5. 26 AugDavenport IA, Iowa, Quad Cities
  6. 27 AugHannibal MO, Missouri
  7. 28 AugAlton IL, Illinois
  8. 28 AugSt Louis MO, Missouri
  9. 28 Aug - 29 AugAlton IL, Illinois
  10. 29 AugArriving in St Louis MO, Missouri
Find this cruise to book →
$5635from / pp
ACL American Melody
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 29 Aug 20267 nights8 portsDeparts 2026 Aug 29
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 29 AugDeparting from St Louis MO, Missouri
  2. 29 AugSt Louis MO, Missouri
  3. 30 AugHannibal MO, Missouri
  4. 01 SepMuscatine IA, Iowa
  5. 02 SepDubuque IA, Iowa
  6. 03 SepWinona MN, Minnesota
  7. 04 SepRed Wing MN, Minnesota
  8. 05 SepArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5635from / pp
American Heritage
American Cruise Lines Cruises
Pittsburgh PA → St Louis MO
⚓ Calls 04 Sep 202613 nights10 portsDeparts 2026 Aug 22
View itinerary · 10 ports
13 days, one-way from Pittsburgh PA to St Louis MO
  1. 22 AugDeparting from Pittsburgh PA, Pennsylvania
  2. 22 AugPittsburgh PA, Pennsylvania
  3. 24 AugMarietta OH, Ohio
  4. 26 AugMaysville KY, Kentucky
  5. 27 AugCincinnati OH, Ohio
  6. 28 AugMadison IN, Indiana
  7. 29 AugLouisville KY, Kentucky
  8. 31 AugHenderson KY, Kentucky
  9. 02 SepPaducah KY, Kentucky
  10. 04 SepArriving in St Louis MO, Missouri
Find this cruise to book →
$8075from / pp
ACL American Serenade
American Cruise Lines Cruises
Minneapolis-Saint Paul → St Louis MO
⚓ Calls 04 Sep 20267 nights10 portsDeparts 2026 Aug 29
View itinerary · 10 ports
7 days, one-way from Minneapolis-Saint Paul to St Louis MO
  1. 29 AugDeparting from Minneapolis-Saint Paul, Minnesota
  2. 29 AugMinneapolis-Saint Paul, Minnesota
  3. 30 AugLa Crosse WI, Wisconsin
  4. 01 SepDubuque IA, Iowa
  5. 02 SepDavenport IA, Iowa, Quad Cities
  6. 03 SepHannibal MO, Missouri
  7. 04 SepAlton IL, Illinois
  8. 04 SepSt Louis MO, Missouri
  9. 04 Sep - 05 SepAlton IL, Illinois
  10. 05 SepArriving in St Louis MO, Missouri
Find this cruise to book →
$5635from / pp
American Heritage
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 05 Sep 20267 nights8 portsDeparts 2026 Sep 05
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 05 SepDeparting from St Louis MO, Missouri
  2. 05 SepSt Louis MO, Missouri
  3. 06 SepHannibal MO, Missouri
  4. 08 SepMuscatine IA, Iowa
  5. 09 SepDubuque IA, Iowa
  6. 10 SepWinona MN, Minnesota
  7. 11 SepRed Wing MN, Minnesota
  8. 12 SepArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$4610from / pp
ACL American Serenade
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 05 Sep 20267 nights8 portsDeparts 2026 Sep 05
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 05 SepDeparting from St Louis MO, Missouri
  2. 05 SepSt Louis MO, Missouri
  3. 06 SepHannibal MO, Missouri
  4. 08 SepMuscatine IA, Iowa
  5. 09 SepDubuque IA, Iowa
  6. 10 SepWinona MN, Minnesota
  7. 11 SepRed Wing MN, Minnesota
  8. 12 SepArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5635from / pp
ACL American Melody
American Cruise Lines Cruises
Minneapolis-Saint Paul → St Louis MO
⚓ Calls 11 Sep 20267 nights10 portsDeparts 2026 Sep 05
View itinerary · 10 ports
7 days, one-way from Minneapolis-Saint Paul to St Louis MO
  1. 05 SepDeparting from Minneapolis-Saint Paul, Minnesota
  2. 05 SepMinneapolis-Saint Paul, Minnesota
  3. 06 SepLa Crosse WI, Wisconsin
  4. 08 SepDubuque IA, Iowa
  5. 09 SepDavenport IA, Iowa, Quad Cities
  6. 10 SepHannibal MO, Missouri
  7. 11 SepAlton IL, Illinois
  8. 11 SepSt Louis MO, Missouri
  9. 11 Sep - 12 SepAlton IL, Illinois
  10. 12 SepArriving in St Louis MO, Missouri
Find this cruise to book →
$5635from / pp
Viking Mississippi
Viking River Cruises
Minneapolis-Saint Paul → New Orleans
⚓ Calls 12 Sep 202614 nights14 portsDeparts 2026 Sep 05
View itinerary · 14 ports
14 days, one-way from Minneapolis-Saint Paul to New Orleans
  1. 05 SepDeparting from Minneapolis-Saint Paul, Minnesota
  2. 06 SepRed Wing MN, Minnesota
  3. 07 SepLa Crosse WI, Wisconsin
  4. 08 SepDubuque IA, Iowa
  5. 09 SepDavenport IA, Iowa, Quad Cities
  6. 10 SepBurlington IA, Iowa
  7. 11 SepHannibal MO, Missouri
  8. 12 SepSt Louis MO, Missouri
  9. 14 SepMemphis TN, Tennessee
  10. 15 SepGreenville MS, Mississippi
  11. 16 SepVicksburg MS, Mississippi
  12. 17 SepNatchez MS, Mississippi
  13. 18 SepBaton Rouge, Louisiana
  14. 19 SepArriving in New Orleans, Port NOLA Louisiana
Find this cruise to book →
Price on request
ACL American Melody
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 12 Sep 20267 nights8 portsDeparts 2026 Sep 12
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 12 SepDeparting from St Louis MO, Missouri
  2. 12 SepSt Louis MO, Missouri
  3. 13 SepHannibal MO, Missouri
  4. 15 SepMuscatine IA, Iowa
  5. 16 SepDubuque IA, Iowa
  6. 17 SepWinona MN, Minnesota
  7. 18 SepRed Wing MN, Minnesota
  8. 19 SepArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5635from / pp
ACL American Serenade
American Cruise Lines Cruises
Minneapolis-Saint Paul → St Louis MO
⚓ Calls 18 Sep 20267 nights10 portsDeparts 2026 Sep 12
View itinerary · 10 ports
7 days, one-way from Minneapolis-Saint Paul to St Louis MO
  1. 12 SepDeparting from Minneapolis-Saint Paul, Minnesota
  2. 12 SepMinneapolis-Saint Paul, Minnesota
  3. 13 SepLa Crosse WI, Wisconsin
  4. 15 SepDubuque IA, Iowa
  5. 16 SepDavenport IA, Iowa, Quad Cities
  6. 17 SepHannibal MO, Missouri
  7. 18 SepAlton IL, Illinois
  8. 18 SepSt Louis MO, Missouri
  9. 18 Sep - 19 SepAlton IL, Illinois
  10. 19 SepArriving in St Louis MO, Missouri
Find this cruise to book →
$5635from / pp
American Heritage
American Cruise Lines Cruises
Minneapolis-Saint Paul → New Orleans
⚓ Calls 19 Sep 202614 nights13 portsDeparts 2026 Sep 12
View itinerary · 13 ports
14 days, one-way from Minneapolis-Saint Paul to New Orleans
  1. 12 SepDeparting from Minneapolis-Saint Paul, Minnesota
  2. 12 SepMinneapolis-Saint Paul, Minnesota
  3. 13 SepLa Crosse WI, Wisconsin
  4. 15 SepDubuque IA, Iowa
  5. 16 SepDavenport IA, Iowa, Quad Cities
  6. 18 SepHannibal MO, Missouri
  7. 19 SepSt Louis MO, Missouri
  8. 21 SepMemphis TN, Tennessee
  9. 22 SepTunica MS, Mississippi
  10. 23 SepVicksburg MS, Mississippi
  11. 24 SepNatchez MS, Mississippi
  12. 25 SepBaton Rouge, Louisiana
  13. 26 SepArriving in New Orleans, Port NOLA Louisiana
Find this cruise to book →
$11030from / pp
ACL American Serenade
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 19 Sep 20267 nights8 portsDeparts 2026 Sep 19
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 19 SepDeparting from St Louis MO, Missouri
  2. 19 SepSt Louis MO, Missouri
  3. 20 SepHannibal MO, Missouri
  4. 22 SepMuscatine IA, Iowa
  5. 23 SepDubuque IA, Iowa
  6. 24 SepWinona MN, Minnesota
  7. 25 SepRed Wing MN, Minnesota
  8. 26 SepArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5635from / pp
ACL American Melody
American Cruise Lines Cruises
Minneapolis-Saint Paul → St Louis MO
⚓ Calls 25 Sep 20267 nights10 portsDeparts 2026 Sep 19
View itinerary · 10 ports
7 days, one-way from Minneapolis-Saint Paul to St Louis MO
  1. 19 SepDeparting from Minneapolis-Saint Paul, Minnesota
  2. 19 SepMinneapolis-Saint Paul, Minnesota
  3. 20 SepLa Crosse WI, Wisconsin
  4. 22 SepDubuque IA, Iowa
  5. 23 SepDavenport IA, Iowa, Quad Cities
  6. 24 SepHannibal MO, Missouri
  7. 25 SepAlton IL, Illinois
  8. 25 SepSt Louis MO, Missouri
  9. 25 Sep - 26 SepAlton IL, Illinois
  10. 26 SepArriving in St Louis MO, Missouri
Find this cruise to book →
$5635from / pp
ACL American Melody
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 26 Sep 20267 nights8 portsDeparts 2026 Sep 26
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 26 SepDeparting from St Louis MO, Missouri
  2. 26 SepSt Louis MO, Missouri
  3. 27 SepHannibal MO, Missouri
  4. 29 SepMuscatine IA, Iowa
  5. 30 SepDubuque IA, Iowa
  6. 01 OctWinona MN, Minnesota
  7. 02 OctRed Wing MN, Minnesota
  8. 03 OctArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5635from / pp
ACL American Serenade
American Cruise Lines Cruises
Minneapolis-Saint Paul → New Orleans
⚓ Calls 03 Oct 202614 nights13 portsDeparts 2026 Sep 26
View itinerary · 13 ports
14 days, one-way from Minneapolis-Saint Paul to New Orleans
  1. 26 SepDeparting from Minneapolis-Saint Paul, Minnesota
  2. 26 SepMinneapolis-Saint Paul, Minnesota
  3. 27 SepLa Crosse WI, Wisconsin
  4. 29 SepDubuque IA, Iowa
  5. 30 SepDavenport IA, Iowa, Quad Cities
  6. 02 OctHannibal MO, Missouri
  7. 03 OctSt Louis MO, Missouri
  8. 05 OctMemphis TN, Tennessee
  9. 06 OctTunica MS, Mississippi
  10. 07 OctVicksburg MS, Mississippi
  11. 08 OctNatchez MS, Mississippi
  12. 09 OctBaton Rouge, Louisiana
  13. 10 OctArriving in New Orleans, Port NOLA Louisiana
Find this cruise to book →
$12620from / pp
ACL American Melody
American Cruise Lines Cruises
Minneapolis-Saint Paul → St Louis MO
⚓ Calls 09 Oct 20267 nights10 portsDeparts 2026 Oct 03
View itinerary · 10 ports
7 days, one-way from Minneapolis-Saint Paul to St Louis MO
  1. 03 OctDeparting from Minneapolis-Saint Paul, Minnesota
  2. 03 OctMinneapolis-Saint Paul, Minnesota
  3. 04 OctLa Crosse WI, Wisconsin
  4. 06 OctDubuque IA, Iowa
  5. 07 OctDavenport IA, Iowa, Quad Cities
  6. 08 OctHannibal MO, Missouri
  7. 09 OctAlton IL, Illinois
  8. 09 OctSt Louis MO, Missouri
  9. 09 Oct - 10 OctAlton IL, Illinois
  10. 10 OctArriving in St Louis MO, Missouri
Find this cruise to book →
$5995from / pp
ACL American Melody
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 10 Oct 20267 nights8 portsDeparts 2026 Oct 10
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 10 OctDeparting from St Louis MO, Missouri
  2. 10 OctSt Louis MO, Missouri
  3. 11 OctHannibal MO, Missouri
  4. 13 OctMuscatine IA, Iowa
  5. 14 OctDubuque IA, Iowa
  6. 15 OctWinona MN, Minnesota
  7. 16 OctRed Wing MN, Minnesota
  8. 17 OctArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5995from / pp
ACL American Melody
American Cruise Lines Cruises
Minneapolis-Saint Paul → New Orleans
⚓ Calls 24 Oct 202614 nights13 portsDeparts 2026 Oct 17
View itinerary · 13 ports
14 days, one-way from Minneapolis-Saint Paul to New Orleans
  1. 17 OctDeparting from Minneapolis-Saint Paul, Minnesota
  2. 17 OctMinneapolis-Saint Paul, Minnesota
  3. 18 OctLa Crosse WI, Wisconsin
  4. 20 OctDubuque IA, Iowa
  5. 21 OctDavenport IA, Iowa, Quad Cities
  6. 23 OctHannibal MO, Missouri
  7. 24 OctSt Louis MO, Missouri
  8. 26 OctMemphis TN, Tennessee
  9. 27 OctTunica MS, Mississippi
  10. 28 OctVicksburg MS, Mississippi
  11. 29 OctNatchez MS, Mississippi
  12. 30 OctBaton Rouge, Louisiana
  13. 31 OctArriving in New Orleans, Port NOLA Louisiana
Find this cruise to book →
$12620from / pp
ACL American Melody
American Cruise Lines Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 17 Jun 202721 nights18 portsDeparts 2027 Jun 05
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 05 JunDeparting from New Orleans, Port NOLA Louisiana
  2. 05 JunNew Orleans, Port NOLA Louisiana
  3. 06 JunOak Alley Plantation, Louisiana
  4. 07 JunBaton Rouge, Louisiana
  5. 08 JunSt Francisville LA, Louisiana
  6. 09 JunNatchez MS, Mississippi
  7. 10 JunVicksburg MS, Mississippi
  8. 11 JunGreenville MS, Mississippi
  9. 12 JunTunica MS, Mississippi
  10. 13 JunMemphis TN, Tennessee
  11. 15 JunCape Girardeau MO, Missouri
  12. 17 JunSt Louis MO, Missouri
  13. 19 JunHannibal MO, Missouri
  14. 21 JunMuscatine IA, Iowa
  15. 22 JunDubuque IA, Iowa
  16. 24 JunWinona MN, Minnesota
  17. 25 JunRed Wing MN, Minnesota
  18. 26 JunArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$15890from / pp
ACL American Serenade
American Cruise Lines Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 24 Jun 202721 nights18 portsDeparts 2027 Jun 12
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 12 JunDeparting from New Orleans, Port NOLA Louisiana
  2. 12 JunNew Orleans, Port NOLA Louisiana
  3. 13 JunOak Alley Plantation, Louisiana
  4. 14 JunBaton Rouge, Louisiana
  5. 15 JunSt Francisville LA, Louisiana
  6. 16 JunNatchez MS, Mississippi
  7. 17 JunVicksburg MS, Mississippi
  8. 18 JunGreenville MS, Mississippi
  9. 19 JunTunica MS, Mississippi
  10. 20 JunMemphis TN, Tennessee
  11. 22 JunCape Girardeau MO, Missouri
  12. 24 JunSt Louis MO, Missouri
  13. 26 JunHannibal MO, Missouri
  14. 28 JunMuscatine IA, Iowa
  15. 29 JunDubuque IA, Iowa
  16. 01 JulWinona MN, Minnesota
  17. 02 JulRed Wing MN, Minnesota
  18. 03 JulArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$15890from / pp
ACL American Melody
American Cruise Lines Cruises
Minneapolis-Saint Paul → St Louis MO
⚓ Calls 02 Jul 20277 nights10 portsDeparts 2027 Jun 26
View itinerary · 10 ports
7 days, one-way from Minneapolis-Saint Paul to St Louis MO
  1. 26 JunDeparting from Minneapolis-Saint Paul, Minnesota
  2. 26 JunMinneapolis-Saint Paul, Minnesota
  3. 27 JunLa Crosse WI, Wisconsin
  4. 29 JunDubuque IA, Iowa
  5. 30 JunDavenport IA, Iowa, Quad Cities
  6. 01 JulHannibal MO, Missouri
  7. 02 JulAlton IL, Illinois
  8. 02 JulSt Louis MO, Missouri
  9. 02 Jul - 03 JulAlton IL, Illinois
  10. 03 JulArriving in St Louis MO, Missouri
Find this cruise to book →
$5635from / pp
ACL American Melody
American Cruise Lines Cruises
St Louis MO → Pittsburgh PA
⚓ Calls 03 Jul 202713 nights10 portsDeparts 2027 Jul 03
View itinerary · 10 ports
13 days, one-way from St Louis MO to Pittsburgh PA
  1. 03 JulDeparting from St Louis MO, Missouri
  2. 03 JulAlton IL, Illinois
  3. 04 JulPaducah KY, Kentucky
  4. 06 JulHenderson KY, Kentucky
  5. 08 JulLouisville KY, Kentucky
  6. 09 JulMadison IN, Indiana
  7. 10 JulCincinnati OH, Ohio
  8. 12 JulMaysville KY, Kentucky
  9. 14 JulMarietta OH, Ohio
  10. 16 JulArriving in Pittsburgh PA, Pennsylvania
Find this cruise to book →
$9240from / pp
ACL American Serenade
American Cruise Lines Cruises
Minneapolis-Saint Paul → St Louis MO
⚓ Calls 09 Jul 20277 nights10 portsDeparts 2027 Jul 03
View itinerary · 10 ports
7 days, one-way from Minneapolis-Saint Paul to St Louis MO
  1. 03 JulDeparting from Minneapolis-Saint Paul, Minnesota
  2. 03 JulMinneapolis-Saint Paul, Minnesota
  3. 04 JulLa Crosse WI, Wisconsin
  4. 06 JulDubuque IA, Iowa
  5. 07 JulDavenport IA, Iowa, Quad Cities
  6. 08 JulHannibal MO, Missouri
  7. 09 JulAlton IL, Illinois
  8. 09 JulSt Louis MO, Missouri
  9. 09 Jul - 10 JulAlton IL, Illinois
  10. 10 JulArriving in St Louis MO, Missouri
Find this cruise to book →
$5635from / pp
ACL American Serenade
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 10 Jul 20277 nights8 portsDeparts 2027 Jul 10
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 10 JulDeparting from St Louis MO, Missouri
  2. 10 JulSt Louis MO, Missouri
  3. 11 JulHannibal MO, Missouri
  4. 13 JulMuscatine IA, Iowa
  5. 14 JulDubuque IA, Iowa
  6. 15 JulWinona MN, Minnesota
  7. 16 JulRed Wing MN, Minnesota
  8. 17 JulArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5635from / pp
Viking Mississippi
Viking River Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 18 Jul - 19 Jul 202721 nights18 portsDeparts 2027 Jul 06
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 06 JulDeparting from New Orleans, Port NOLA Louisiana
  2. 07 JulDarrow LA, Louisiana
  3. 08 JulSt Francisville LA, Louisiana
  4. 09 JulNatchez MS, Mississippi
  5. 10 JulVicksburg MS, Mississippi
  6. 11 JulGreenville MS, Mississippi
  7. 13 Jul - 14 JulMemphis TN, Tennessee
  8. 16 JulPaducah KY, Kentucky
  9. 17 JulCape Girardeau MO, Missouri
  10. 18 Jul - 19 JulSt Louis MO, Missouri
  11. 20 JulAlton IL, Illinois
  12. 21 JulHannibal MO, Missouri
  13. 22 JulBurlington IA, Iowa
  14. 23 JulDavenport IA, Iowa, Quad Cities
  15. 24 JulDubuque IA, Iowa
  16. 25 JulLa Crosse WI, Wisconsin
  17. 26 JulRed Wing MN, Minnesota
  18. 27 JulArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$15998from / pp
Viking Mississippi
Viking River Cruises
New Orleans → Alton IL
⚓ Calls 18 Jul - 19 Jul 202714 nights11 portsDeparts 2027 Jul 06
View itinerary · 11 ports
14 days, one-way from New Orleans to Alton IL
  1. 06 JulDeparting from New Orleans, Port NOLA Louisiana
  2. 07 JulDarrow LA, Louisiana
  3. 08 JulSt Francisville LA, Louisiana
  4. 09 JulNatchez MS, Mississippi
  5. 10 JulVicksburg MS, Mississippi
  6. 11 JulGreenville MS, Mississippi
  7. 13 Jul - 14 JulMemphis TN, Tennessee
  8. 16 JulPaducah KY, Kentucky
  9. 17 JulCape Girardeau MO, Missouri
  10. 18 Jul - 19 JulSt Louis MO, Missouri
  11. 20 JulArriving in Alton IL, Illinois
Find this cruise to book →
$9999from / pp
ACL American Serenade
American Cruise Lines Cruises
Minneapolis-Saint Paul → St Louis MO
⚓ Calls 23 Jul 20277 nights10 portsDeparts 2027 Jul 17
View itinerary · 10 ports
7 days, one-way from Minneapolis-Saint Paul to St Louis MO
  1. 17 JulDeparting from Minneapolis-Saint Paul, Minnesota
  2. 17 JulMinneapolis-Saint Paul, Minnesota
  3. 18 JulLa Crosse WI, Wisconsin
  4. 20 JulDubuque IA, Iowa
  5. 21 JulDavenport IA, Iowa, Quad Cities
  6. 22 JulHannibal MO, Missouri
  7. 23 JulAlton IL, Illinois
  8. 23 JulSt Louis MO, Missouri
  9. 23 Jul - 24 JulAlton IL, Illinois
  10. 24 JulArriving in St Louis MO, Missouri
Find this cruise to book →
$5635from / pp
ACL American Serenade
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 24 Jul 20277 nights8 portsDeparts 2027 Jul 24
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 24 JulDeparting from St Louis MO, Missouri
  2. 24 JulSt Louis MO, Missouri
  3. 25 JulHannibal MO, Missouri
  4. 27 JulMuscatine IA, Iowa
  5. 28 JulDubuque IA, Iowa
  6. 29 JulWinona MN, Minnesota
  7. 30 JulRed Wing MN, Minnesota
  8. 31 JulArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5635from / pp
ACL American Melody
American Cruise Lines Cruises
Pittsburgh PA → St Louis MO
⚓ Calls 30 Jul 202713 nights10 portsDeparts 2027 Jul 17
View itinerary · 10 ports
13 days, one-way from Pittsburgh PA to St Louis MO
  1. 17 JulDeparting from Pittsburgh PA, Pennsylvania
  2. 17 JulPittsburgh PA, Pennsylvania
  3. 19 JulMarietta OH, Ohio
  4. 21 JulMaysville KY, Kentucky
  5. 22 JulCincinnati OH, Ohio
  6. 23 JulMadison IN, Indiana
  7. 24 JulLouisville KY, Kentucky
  8. 26 JulHenderson KY, Kentucky
  9. 28 JulPaducah KY, Kentucky
  10. 30 JulArriving in St Louis MO, Missouri
Find this cruise to book →
$9240from / pp
ACL American Melody
American Cruise Lines Cruises
St Louis MO → Minneapolis-Saint Paul
⚓ Calls 31 Jul 20277 nights8 portsDeparts 2027 Jul 31
View itinerary · 8 ports
7 days, one-way from St Louis MO to Minneapolis-Saint Paul
  1. 31 JulDeparting from St Louis MO, Missouri
  2. 31 JulSt Louis MO, Missouri
  3. 01 AugHannibal MO, Missouri
  4. 03 AugMuscatine IA, Iowa
  5. 04 AugDubuque IA, Iowa
  6. 05 AugWinona MN, Minnesota
  7. 06 AugRed Wing MN, Minnesota
  8. 07 AugArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$5635from / pp
Viking Mississippi
Viking River Cruises
Minneapolis-Saint Paul → New Orleans
⚓ Calls 03 Aug 202714 nights14 portsDeparts 2027 Jul 27
View itinerary · 14 ports
14 days, one-way from Minneapolis-Saint Paul to New Orleans
  1. 27 JulDeparting from Minneapolis-Saint Paul, Minnesota
  2. 28 JulRed Wing MN, Minnesota
  3. 29 JulLa Crosse WI, Wisconsin
  4. 30 JulDubuque IA, Iowa
  5. 31 JulDavenport IA, Iowa, Quad Cities
  6. 01 AugBurlington IA, Iowa
  7. 02 AugHannibal MO, Missouri
  8. 03 AugSt Louis MO, Missouri
  9. 05 AugMemphis TN, Tennessee
  10. 06 AugGreenville MS, Mississippi
  11. 07 AugVicksburg MS, Mississippi
  12. 08 AugNatchez MS, Mississippi
  13. 09 AugBaton Rouge, Louisiana
  14. 10 AugArriving in New Orleans, Port NOLA Louisiana
Find this cruise to book →
$12999from / pp

Itineraries and prices change — always confirm with the cruise line before booking. Some links are affiliate links that may earn us a commission at no extra cost to you.